NAD+ 500mg
Original price was: $130.00.$80.00Current price is: $80.00.
NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme involved in cellular redox reactions and energy metabolism research.
Studies often explore NAD+ for its role in mitochondrial activity, oxidative stress modulation, and sirtuin-related pathways.
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ESSENTIAL CELLULAR COENZYME
The Foundation of Cellular Energy and Repair Research
NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in every living cell. Participating in over 500 enzymatic reactions, NAD+ is central to energy metabolism, DNA repair, and mitochondrial function. Research has established that cellular NAD+ levels decline significantly with age — a decline now considered a hallmark of aging and a key target for longevity research.
- Essential coenzyme for 500+ enzymatic reactions
- Central to glycolysis, TCA cycle, and oxidative phosphorylation
- Critical substrate for sirtuins, PARPs, and CD38
- Supports mitochondrial biogenesis and function
- High purity (≥98%) for reliable research outcomes
For laboratory research use only. Not for human consumption.
CELLULAR MECHANISMS
How NAD+ Powers Cellular Function and Repair
NAD+ functions as an electron carrier in redox reactions, shuttling electrons through the metabolic pathways that generate ATP. Beyond energy production, NAD+ serves as an essential substrate for three major enzyme families: sirtuins (longevity-associated deacetylases), PARPs (DNA repair enzymes), and CD38 (NADase involved in immune signaling). This multi-pathway involvement makes NAD+ central to cellular health research.
- Electron carrier for ATP production pathways
- Substrate for sirtuins (SIRT1-7) — key longevity enzymes
- Required for PARP-mediated DNA damage repair
- Modulates CD38 NADase and immune cell signaling
- Regulates circadian rhythm via NAMPT pathway
For laboratory research use only. Not for human consumption.
RESEARCH APPLICATIONS
From Aging Biology to Metabolic Research — Expanding Frontiers
NAD+ has emerged as a cornerstone of longevity and metabolic research. Scientists use it to investigate age-related cellular decline, mitochondrial dysfunction, and metabolic disorders. Its role in sirtuin activation and DNA repair makes it essential for studies exploring healthspan extension, neuroprotection, and cellular rejuvenation. Research demonstrates that restoring NAD+ levels can reverse age-associated mitochondrial dysfunction.
- Aging biology and longevity pathway studies
- Mitochondrial function and bioenergetics research
- DNA damage response and genomic stability
- Metabolic health and insulin sensitivity modeling
- Neuroprotection and cognitive function studies
- Sirtuin activation and caloric restriction mimetics
For laboratory research use only. Not for human consumption.
The Science Behind Cellular Vitality: Why NAD+ Is Central to Longevity Research
NAD+ stands at the crossroads of cellular metabolism, repair, and aging. As a coenzyme present in every living cell, it participates in over 500 enzymatic reactions — from energy production to DNA maintenance. This ubiquitous involvement makes NAD+ one of the most studied molecules in longevity science.
The research is clear: cellular NAD+ levels decline significantly with age, correlating with reduced mitochondrial function, impaired DNA repair, and decreased sirtuin activity. Studies have shown that this decline disrupts nuclear-mitochondrial communication, inducing a pseudohypoxic state that contributes to age-related metabolic dysfunction. This NAD+ decline is now considered a hallmark of aging.
NAD+ serves as the essential substrate for sirtuins — a family of seven enzymes (SIRT1-7) linked to longevity across multiple species. It’s also required for PARPs, the enzymes responsible for detecting and repairing DNA damage, and consumed by CD38, a NADase whose expression increases with age and drives further NAD+ depletion. Research demonstrates that CD38 knockout mice maintain NAD+ levels and mitochondrial function into advanced age.
For research teams investigating aging mechanisms, metabolic health, or cellular resilience, NAD+ provides the foundational tool for exploring how cells maintain function over time. Restoring NAD+ levels in aged mice has been shown to reverse mitochondrial dysfunction to that of young animals — highlighting the preventive and therapeutic potential of NAD+ interventions in aging research.
For research use only. Not for human consumption.
SCIENTIFIC REFERENCES
- Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014;24(8):464-471. PMID: 24786309
- Gomes AP, et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155(7):1624-1638. PMID: 24360282
- Camacho-Pereira J, et al. CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab. 2016;23(6):1127-1139. PMID: 27304511
- Yoshino J, et al. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. PMID: 21982712
- Mills KF, et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016;24(6):795-806. PMID: 28068222
CERTIFICATE
A detailed summary of the analytical profile, purity, and molecular integrity of the research-grade peptide compound.
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